N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid

Base Information

• Chemical Name: N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid
• CAS No.: 72594-94-6
• Molecular Formula: C₂₃H₃₄N₂O₇
• Molecular Weight: 450.532
• Mol file: 72594-94-6.mol

Synonyms:N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid

Chemical Property of N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid

There total 2 articles about N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-tert-Butoxycarbonylamino-3-isocyanato-propionic acid tert-butyl ester → N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid (72594-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 12 h / 60 °C

2: 1.) H₂, 2.) dicyclohexylcarbodiimide / 1.) 10percent Pd/C / 1.) THF, 50 psi, 2 h, 2.) THF, a) 0 deg C, 1 h, b) RT, 12 h

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In toluene;

DOI:10.1021/jm00178a012

Reference yield:

2-benzyl-3-methoxy-3-oxopropanoic acid (54561-75-0) + N-(tert-butyloxycarbonyl)-N'-(benzyloxycarbonyl)-β,β-diaminopropionic acid tert-butyl ester (64789-42-0) → N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid (72594-94-6)

Guidance literature:

With hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; Yield given. Multistep reaction; 1.) THF, 50 psi, 2 h, 2.) THF, a) 0 deg C, 1 h, b) RT, 12 h;

DOI:10.1021/jm00178a012

upstream raw materials:

2-benzyl-3-methoxy-3-oxopropanoic acid

N-(tert-butyloxycarbonyl)-N'-(benzyloxycarbonyl)-β,β-diaminopropionic acid tert-butyl ester