Propanedioic acid, (phenylmethyl)-, monomethyl ester

Base Information

• Chemical Name: Propanedioic acid, (phenylmethyl)-, monomethyl ester
• CAS No.: 54561-75-0
• Molecular Formula: C11H12O4
• Molecular Weight: 208.214
• Mol file: 54561-75-0.mol

Synonyms:2-benzyl-3-methoxy-3-oxopropanoic acid;Propanedioic acid,(phenylmethyl)-,monomethyl ester;Benzylmalonsaeuremonomethylester;methyl 2-benzylmalonate;

Chemical Property of Propanedioic acid, (phenylmethyl)-, monomethyl ester

Chemical Property:

• Boiling Point: 344.0±30.0 °C(Predicted)
• PSA: 66.43000
• Density: 1.222±0.06 g/cm3(Predicted)
• LogP: -0.23180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, (phenylmethyl)-, monomethyl ester

There total 9 articles about Propanedioic acid, (phenylmethyl)-, monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-benzyl-malonic acid benzyl ester methyl ester (607367-17-9) → 2-benzyl-3-methoxy-3-oxopropanoic acid (54561-75-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm048984g

Reference yield: 98.0%

2-benzyl-malonic acid dimethyl ester (49769-78-0) → 2-benzyl-3-methoxy-3-oxopropanoic acid (54561-75-0)

Guidance literature:

With potassium hydroxide; In methanol; at 23 ℃; for 4h;

DOI:10.1002/anie.201402433

Reference yield: 82.0%

carbon dioxide (124-38-9,18923-20-1) + Methyl cinnamate (103-26-4,1754-62-7) → 2-benzyl-3-methoxy-3-oxopropanoic acid (54561-75-0)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; diethylzinc; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

DOI:10.1002/ejoc.201600338

upstream raw materials:

2-benzyl-malonic acid benzyl ester methyl ester

methanol

2-benzylmalonic acid

benzyl bromide

Downstream raw materials:

N-(tert-butyloxycarbonyl)-N'-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-β,β-diaminopropionic acid

benzyl N^β-(benzyloxycarbonyl)-N^α-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-L-α,β-diaminopropionate

benzyl N-<(RS)-α-(methoxycarbonyl)-β-phenylpropionyl>-N'-(benzyloxycarbonyl)-α,α-diaminoacetate

(2S,5S)-1-[(2S,R)-methoxycarbonyl-3-phenyl-propionyl]-5-(2-hydroxyethyl)pyrrolidine-2-carboxylic acid tert-butyl ester