rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

Base Information

Chemical Name:rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide
CAS No.:1369542-55-1
Molecular Formula:C₁₉H₁₇ClN₆O
Molecular Weight:380.837
Hs Code.:

Synonyms:rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

Suppliers and Price of rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

There total 16 articles about rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 86873-60-1
5-chloropicolinic acid

: 1369543-09-8
rac-4-(3-aminophenyl)-4-methyl-4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-amine

: 1369542-55-1
rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

Guidance literature:: 5-chloropicolinic acid; With ammonia; HATU; In dichloromethane; N,N-dimethyl-aniline; at 20 ℃; for 0.166667h;

rac-4-(3-aminophenyl)-4-methyl-4,7-dihydro-pyrazolo[1,5-a]pyrazin-6-amine; In dichloromethane; N,N-dimethyl-aniline; at 20 ℃; for 18h;

Reference yield:

: 1369542-97-1
rac-tert-butyl N-[1-(3-bromophenyl)-1-(1H-pyrazol-3-yl)ethyl]carbamate

: 1369542-55-1
rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: diphosphorus pentasulfide / pyridine / 18 h / 95 °C

5.1: ammonium chloride / ethanol / 28 h / 80 °C

6.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 20 - 100 °C / Sealed tube; Inert atmosphere

7.1: hydrogenchloride / water; isopropyl alcohol / 3 h / 20 °C

8.1: HATU; ammonia / dichloromethane; N,N-dimethyl-aniline / 0.17 h / 20 °C

8.2: 18 h / 20 °C

With hydrogenchloride; diphosphorus pentasulfide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonia; sodium hydride; ammonium chloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; dichloromethane; water; N,N-dimethyl-aniline; isopropyl alcohol; toluene;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1369542-55-1
rac-N-[3-(6-amino-4-methyl-4,7-dihydropyrazolo[1,5-a]pyrazin-4-yl)-phenyl]-5-chloropyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 16 steps

1.1: ammonium chloride; ammonia / methanol / 96 h / 20 °C

2.1: hydrogenchloride / methanol / 96 h / Reflux

2.2: 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

6.1: tetrahydrofuran / 0.75 h / 0 - 20 °C / Inert atmosphere

7.1: Dess-Martin periodane / dichloromethane / 1.25 h / 0 - 20 °C

8.1: hydrazine / ethanol / 1 h / 20 °C

9.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Cooling with ice

11.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

12.1: diphosphorus pentasulfide / pyridine / 18 h / 95 °C

13.1: ammonium chloride / ethanol / 28 h / 80 °C

14.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 20 - 100 °C / Sealed tube; Inert atmosphere

15.1: hydrogenchloride / water; isopropyl alcohol / 3 h / 20 °C

16.1: HATU; ammonia / dichloromethane; N,N-dimethyl-aniline / 0.17 h / 20 °C

16.2: 18 h / 20 °C

With hydrogenchloride; diphosphorus pentasulfide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; ammonia; sodium hydride; sodium hydrogencarbonate; ammonium chloride; Dess-Martin periodane; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; sodium t-butanolate; hydrazine; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; water; N,N-dimethyl-aniline; isopropyl alcohol; toluene;