4-(2-(diethylamino)ethoxy)-2-methoxybenzamine

Base Information

• Chemical Name: 4-(2-(diethylamino)ethoxy)-2-methoxybenzamine
• CAS No.: 882670-67-9
• Molecular Formula: C₁₃H₂₂N₂O₂
• Molecular Weight: 238.33
• Mol file: 882670-67-9.mol

Synonyms:4-(2-(diethylamino)ethoxy)-2-methoxybenzamine

Chemical Property of 4-(2-(diethylamino)ethoxy)-2-methoxybenzamine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(diethylamino)ethoxy)-2-methoxybenzamine

There total 4 articles about 4-(2-(diethylamino)ethoxy)-2-methoxybenzamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N,N-diethyl-2-(3-methoxy-4-nitrophenoxy)ethanamine (1240199-76-1) → 4-(2-(diethylamino)ethoxy)-2-methoxybenzamine (882670-67-9)

Guidance literature:

With tin(II) chloride dihdyrate; In ethanol; for 3h; Reflux;

DOI:10.1007/s12272-015-0596-5

Reference yield: 67.0%

→ 4-(2-(diethylamino)ethoxy)-2-methoxybenzamine (882670-67-9)

Guidance literature:

With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;

Reference yield:

2-(Diethylamino)ethanol (100-37-8) → 4-(2-(diethylamino)ethoxy)-2-methoxybenzamine (882670-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2: tin(II) chloride dihdyrate / ethanol / 3 h / Reflux

With tin(II) chloride dihdyrate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethanol; 1: |Mitsunobu Displacement;

DOI:10.1007/s12272-015-0596-5

upstream raw materials:

N,N-diethyl-2-(3-methoxy-4-nitrophenoxy)ethanamine

2-(Diethylamino)ethanol

4-nitro-3-methoxyphenol