3-methoxy-4-nitrophenol

Base Information

• Chemical Name: 3-methoxy-4-nitrophenol
• CAS No.: 16292-95-8
• Molecular Formula: C7H7NO4
• Molecular Weight: 169.137
• Hs Code.: 2909500000
• Mol file: 16292-95-8.mol

Synonyms:3-Methoxy-4-nitrophenol;

Chemical Property of 3-methoxy-4-nitrophenol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 144 °C
• Refractive Index: 1.583
• Boiling Point: 356.207 °C at 760 mmHg
• PKA: 7.13±0.10(Predicted)
• Flash Point: 169.229 °C
• PSA: 75.28000
• Density: 1.367 g/cm³
• LogP: 1.83220
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Methoxy-4-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 3-methoxy-4-nitrophenol serves diverse purposes across various fields, each with a distinct role. In the realm of organic synthesis, this compound acts as a building block for the creation of complex molecules, contributing to advancements in chemical research and the development of new materials. In the pharmaceutical industry, it plays a crucial role as an intermediate in the synthesis of medications, aiding in the production of pharmaceutical compounds with specific properties. Additionally, 3-methoxy-4-nitrophenol finds utility in the field of agriculture as a precursor in the formulation of pesticides and herbicides, contributing to pest management and crop protection. Its versatile applications in organic chemistry, pharmaceuticals, and agriculture highlight its importance in driving innovation and progress in these respective areas.

Technology Process of 3-methoxy-4-nitrophenol

There total 16 articles about 3-methoxy-4-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-4-nitrophenol (394-41-2) + sodium methylate (124-41-4) → 4-nitro-3-methoxyphenol (16292-95-8)

Guidance literature:

With potassium carbonate; In methanol; for 168h; Reflux;

DOI:10.1021/jm900242c

Reference yield: 95.0%

4-fluoro-2-methoxy-1-nitrobenzene (448-19-1) → 4-nitro-3-methoxyphenol (16292-95-8)

Guidance literature:

4-fluoro-2-methoxy-1-nitrobenzene; With water; sodium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 20h;

With hydrogenchloride; In water; dimethyl sulfoxide; at 20 ℃; pH=5;

Reference yield: 91.0%

methanol (67-56-1) + 3-fluoro-4-nitrophenol (394-41-2) → 4-nitro-3-methoxyphenol (16292-95-8)

Guidance literature:

With sodium; for 12h; Reflux;

upstream raw materials:

O-methylresorcine

2-hydroxy-4-methoxy-5-nitrobenzoic acid

4-fluoro-2-methoxy-1-nitrobenzene

2-Nitroanisole

Downstream raw materials:

1-iodo-4-methoxy-5-nitro-2-phenoxy-benzene

1-(difluoromethoxy)-3-methoxy-4-nitrobenzene

(2'R,3'S,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid [4-(2-hydroxy-ethoxy)-2-methoxy-phenyl]-amide

7-methoxy-4-(3-methoxy-4-nitrophenoxy)quinoline

Refernces

• 1、 -. "COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF". Paragraph 459-461. . Retrieved 2019/08/29.
• 2、 -. "TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME". Paragraph 0211; 0212. . Retrieved 2018/03/25.