tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

Base Information

Chemical Name:tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate
CAS No.:1349770-59-7
Molecular Formula:C₃₀H₃₈BrN₅O₇
Molecular Weight:660.565
Hs Code.:

Synonyms:tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

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Chemical Property of tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

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Technology Process of tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

There total 4 articles about tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1349770-57-5
tert-butyl N-[[4-[5-(2-amino-5-bromo-3-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

: 1349770-59-7
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

Guidance literature:: di-tert-butyl dicarbonate; tert-butyl N-[[4-[5-(2-amino-5-bromo-3-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate; With dmap; In tetrahydrofuran; at 20 ℃; for 6h;

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 - 60 ℃; for 82h;

Reference yield:

: 1232424-40-6
tert-butyl N-[[4-(hydrazinecarbonyl)phenyl]methyl]-N-methyl-carbamate

: 1349770-59-7
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 60 h / 20 °C

2.1: dibromotriphenylphosphorane; N-ethyl-N,N-diisopropylamine / acetonitrile / 15.67 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: dmap / tetrahydrofuran / 6 h / 20 °C

3.2: 82 h / 20 - 60 °C

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; dibromotriphenylphosphorane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1349770-55-3
tert-butyl N-[[4-[[(2-amino-5-bromo-pyridine-3-carbonyl)amino]carbamoyl]phenyl]methyl]-N-methyl-carbamate

: 1349770-59-7
tert-butyl N-[[4-[5-[2-[bis(tert-butoxycarbonyl)amino]-5-bromo-3-pyridyl]-1,3,4-oxadiazol-2-yl]phenyl]methyl]-N-methyl-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibromotriphenylphosphorane; N-ethyl-N,N-diisopropylamine / acetonitrile / 15.67 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: dmap / tetrahydrofuran / 6 h / 20 °C

2.2: 82 h / 20 - 60 °C

With dmap; N-ethyl-N,N-diisopropylamine; dibromotriphenylphosphorane; In tetrahydrofuran; acetonitrile;