5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

Base Information

Chemical Name:5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one
CAS No.:950679-04-6
Molecular Formula:C₅₀H₆₉N₃O₅Si
Molecular Weight:820.2
Hs Code.:

5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

Synonyms:5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

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Chemical Property of 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

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Technology Process of 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

There total 6 articles about 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950679-03-5
8-(benzyloxy)-5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one

: 950679-04-6
5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

Guidance literature:: With ammonium formate; palladium(II) hydroxide/carbon; In ethanol; at 70 ℃; for 3h;

Reference yield:

: C₄₅H₅₈N₂O₄

: 950679-04-6
5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on carbon; hydrogen / ethanol

2: hydrogenchloride; water / diethyl ether; ethanol

3: sodium hydrogencarbonate / acetonitrile

4: ammonium formate; palladium(II) hydroxide / methanol

With hydrogenchloride; palladium on carbon; water; hydrogen; ammonium formate; palladium(II) hydroxide; sodium hydrogencarbonate; In methanol; diethyl ether; ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2010.10.132

Reference yield:

: 950773-38-3
R-(-)-[3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl]diisopropylamine

: 950679-04-6
5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / acetonitrile

2: palladium on carbon; hydrogen / ethanol

3: hydrogenchloride; water / diethyl ether; ethanol

4: sodium hydrogencarbonate / acetonitrile

5: ammonium formate; palladium(II) hydroxide / methanol

With hydrogenchloride; palladium on carbon; water; hydrogen; palladium diacetate; ammonium formate; palladium(II) hydroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In methanol; diethyl ether; ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2010.10.132