950773-38-3Relevant articles and documents
PROCESS FOR THE PREPARATION OF FESOTERODINE OR ITS SALTS
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, (2013/04/13)
The present invention relates to a process for the preparation of fesoterodine or its salts.
SOLID STATE FORMS OF FESOTERODINE INTERMEDIATES
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Page/Page column 7, (2011/06/19)
Provided herein are novel solid state forms of fesoterodine intermediates, (R)-4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-benzoic acid and (R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-phenyl]-methanol, and processes for their preparation thereof. The solid state intermediates are useful for preparing fesoterodine or a pharmaceutically acceptable salt thereof in high purity.
A shortened synthesis of substituted hydroxymethyl phenols
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Page/Page column 12, (2008/06/13)
The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formula (II) with a mixture of MeMgCl and Mg in a solvent, b) optionally reducing the temperature of the Grignard reagent to a lower temperature than in step a), and reacting the resulting Grignard reagent with an excess of a carbonate in a solvent, to obtain a compound of formula (III) wherein A is a C1-C6 alkyl group, and then further reacting the compound of formula (III) in a known manner to obtain the desired end product.