950773-38-3

Basic information

• Product Name: Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)-
• Synonyms: Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)-;BenzenepropanaMine, 5-broMo-N,N-bis(1-Methylethyl)-g-phenyl-2-(phenylMethoxy)-, (gR)-;(R)-3-(2-(Benzyloxy)-5-bromophenyl)-N,N-diisopropyl-3-phenylpropan-1-amine;(γR)-5-Bromo-N,N-bis(1-methylethyl)-γ-phenyl-2-(phenylmethoxy)benzenepropanamine
• CAS NO: 950773-38-3
• Molecular Formula: C₂₈H₃₄BrNO
• Molecular Weight: 480.47966
• Mol File: 950773-38-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)-(950773-38-3)
• EPA Substance Registry System: Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)-(950773-38-3)

Safety Data

• Hazardous Substances Data: 950773-38-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)is utilized as a potential drug candidate in the pharmaceutical industry due to its unique chemical structure and potential biological activity. Its specific application in drug development is yet to be fully explored, but its properties indicate that it may contribute to the discovery of new therapeutic agents.
Used in Research:
In the field of scientific research, Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)serves as a valuable research tool. Its chemical structure and potential biological activity make it suitable for studying various biological processes and mechanisms. Researchers can leverage Benzenepropanamine, 5-bromo-N,N-bis(1-methylethyl)-.gamma.-phenyl-2-(phenylmethoxy)-, (.gamma.R)- to investigate its interactions with biological systems, potentially leading to new insights and advancements in multiple scientific fields.

Upstream product

• 1429299-06-8 R-(-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid (1S,2R)-ephedrine salt 
• 1185739-54-1 (+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid 
• 156755-24-7 methyl 3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoate 
• 100-44-7 benzyl chloride 
• 156755-23-6 6-bromo-4-phenyl-3,4-dihydro-2H-chromen-2-one 
• 1429299-08-0 R-(-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionamide 
• 1429299-07-9 (3R)-3-[2-(benzyloxy)-5-bromophenyl]-3-phenylpropanoyl chloride 
• 865889-33-4 R-(-)3-(2-benzyloxy-5-bromophenyl)-3-phenylpropionic acid 
• 1361197-27-4 3-(2-(benzyloxy)-5-bromophenyl)-3-phenylpropyl methanesulfonate 
• 621-82-9 Cinnamic acid 
• 1135493-18-3 C₂₀H₁₈O₈*C₂₈H₃₄BrNO 
• 250214-37-0 (+/-)-toluene-4-sulphonic acid 3-(2-benzyloxy-5-bromophenyl)-3-phenylpropyl ester 
• 106-41-2 4-bromo-phenol 
• 140-10-3 (E)-3-phenylacrylic acid 

Downstream Products

• 156755-33-8 (R)-4-(benzyloxy)-3-(3-(diisopropylamino)-1-phenylpropyl)benzoic acid hydrochloride 
• 754159-68-7 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoic acid 
• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 286930-02-7 fesoterodine 
• 286930-03-8 fesoterodine fumarate 
• 286930-03-8 2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenyl 2-methylpropanoate fumarate 
• 950678-83-8 tert-butyl {2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}carbamate 
• 950679-04-6 5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]-8-hydroxyquinolin-2(1H)-one 
• 950679-03-5 8-(benzyloxy)-5-[(1R)-1-{[tert-butyl(dimethyl)silyl]oxy}-2-({2-[4-(4-{3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-hydroxyphenyl}butoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one 
• 950679-01-3 C₃₃H₄₆N₂O₂ 
• 156755-37-2 {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol 
• 156755-35-0 methyl 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoate 
• 950679-35-3 di-tert-butyl [(7E)-8-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}oct-7-en-1-yl]imidodicarbonate 
• 950678-95-2 6-{[(3E)-4-{4-(benzyloxy)-3-[(1R)-3-(diisopropylamino)-1-phenylpropyl]phenyl}but-3-en-1-yl]oxy}hexanenitrile 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF FESOTERODINE OR ITS SALTS

The present invention relates to a process for the preparation of fesoterodine or its salts.

PROCESSES FOR THE PREPARATION OF FESOTERODINE

The invention relates to improved process for the preparation of fesoterodine and its pharmaceutically acceptable salt, specifically fesoterodine fumarate of formula (1). The invention relates to solid state forms of a novel salt of fesoterodine and process for the preparation thereof. The invention also relates to highly pure fesoterodine fumarate substantially free of impurity X at RRT 1.37. The invention also provides solid particles of pure fesoterodine fumarate wherein 90 volume-percent of the particles (D90) have a size of higher than 200 microns.

SOLID STATE FORMS OF FESOTERODINE INTERMEDIATES

Provided herein are novel solid state forms of fesoterodine intermediates, (R)-4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-benzoic acid and (R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-phenyl]-methanol, and processes for their preparation thereof. The solid state intermediates are useful for preparing fesoterodine or a pharmaceutically acceptable salt thereof in high purity.

ACCELERATED SYNTHESIS OF SUBSTITUTED HYDROXYMETHYL PHENOLS

This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof , comprising the following steps

A shortened synthesis of substituted hydroxymethyl phenols

The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formula (II) with a mixture of MeMgCl and Mg in a solvent, b) optionally reducing the temperature of the Grignard reagent to a lower temperature than in step a), and reacting the resulting Grignard reagent with an excess of a carbonate in a solvent, to obtain a compound of formula (III) wherein A is a C1-C6 alkyl group, and then further reacting the compound of formula (III) in a known manner to obtain the desired end product.