3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Base Information

• Chemical Name: 3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide
• CAS No.: 1061091-60-8
• Molecular Formula: C₂₂H₁₇BrClN₃O₃S
• Molecular Weight: 518.818

Synonyms:3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Chemical Property of 3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide

There total 2 articles about 3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-[(4-bromophenyl)sulfonyl]carbamic acid methyl ester (7018-75-9) + 3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole (59074-26-9) → 3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide (1061091-60-8)

Guidance literature:

In toluene; Reflux;

DOI:10.1021/jm800329z

Reference yield:

4-bromo-benzenesulfonic acid amide (701-34-8) → 3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide (1061091-60-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 0 - 20 °C

2: toluene / 5 h / Reflux

With triethylamine; In toluene; acetonitrile;

DOI:10.1021/acs.jmedchem.6b01504

Reference yield:

3-(4-chlorophenyl)-N-[(4-bromophenyl)sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide (1061091-60-8) → C22H16BrCl2N3O2S

Guidance literature:

With phosphorus pentachloride; In chlorobenzene; Reflux;

DOI:10.1021/jm800329z

upstream raw materials:

N-[(4-bromophenyl)sulfonyl]carbamic acid methyl ester

3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole

4-bromo-benzenesulfonic acid amide

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