tert-butyl {(1S)-2-[5-bromo-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}carbamate

Base Information

Chemical Name:tert-butyl {(1S)-2-[5-bromo-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}carbamate
CAS No.:848121-45-9
Molecular Formula:C₂₅H₂₆BrF₂N₃O₄
Molecular Weight:550.4
Hs Code.:

Synonyms:3-[(2S)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-bromo-6-methyluracil

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Chemical Property of tert-butyl {(1S)-2-[5-bromo-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}carbamate

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl {(1S)-2-[5-bromo-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}carbamate

There total 1 articles about tert-butyl {(1S)-2-[5-bromo-3-(2,6-difluorobenzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117049-14-6
tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

: 352303-66-3
5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

: 848121-45-9
3-[(2S)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-bromo-6-methyluracil

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jm049218c

Reference yield:

: 848121-45-9
3-[(2S)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-bromo-6-methyluracil

: 352303-67-4
(2-fluoro-3-methoxyphenyl)boronic acid

: {2-[3-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; benzene; at 80 ℃;
DOI:10.1021/jm049218c

Reference yield:

: 848121-45-9
3-[(2S)-(tert-butoxycarconylamino)-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-bromo-6-methyluracil

: 352290-59-6
3-(2-amino-2-phenyl-ethyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Ba(OH)2; tetrakis(triphenylphosphine)palladium / benzene; ethanol; 1,2-dimethoxy-ethane / 80 °C

2: TFA / CH₂Cl₂ / 20 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; benzene; 1: Suzuki coupling;
DOI:10.1021/jm049218c