4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate

Base Information

• Chemical Name: 4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate
• CAS No.: 1292298-69-1
• Molecular Formula: C₂HF₃O₂*C₁₂H₁₅NO₅
• Molecular Weight: 367.279
• Mol file: 1292298-69-1.mol

Synonyms:4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate

Chemical Property of 4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate

There total 4 articles about 4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(2,4-dihydroxyphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate (1292298-99-7) + trifluoroacetic acid (76-05-1) → 4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate (1292298-69-1)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1139/V10-143

Reference yield:

1-[2,4-bis(benzyloxy)phenyl]-2-bromoethan-1-one (719288-40-1) → 4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate (1292298-69-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

3: dichloromethane / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In dichloromethane; ethyl acetate; acetonitrile;

DOI:10.1139/V10-143

Reference yield:

2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate (1292298-98-6) → 4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate (1292298-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

2: dichloromethane / 20 °C

With palladium 10% on activated carbon; hydrogen; In dichloromethane; ethyl acetate;

DOI:10.1139/V10-143

upstream raw materials:

1-[2,4-bis(benzyloxy)phenyl]-2-bromoethan-1-one

2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

2-(2,4-dihydroxyphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

trifluoroacetic acid