2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Base Information

• Chemical Name: 2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate
• CAS No.: 1292298-98-6
• Molecular Formula: C₃₁H₃₅NO₇
• Molecular Weight: 533.621

Synonyms:2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Chemical Property of 2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

Chemical Property:

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Technology Process of 2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

There total 2 articles about 2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-[2,4-bis(benzyloxy)phenyl]-2-bromoethan-1-one (719288-40-1) + N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) → 2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate (1292298-98-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1139/V10-143

Reference yield:

2,4-bis(benzyloxy)acetophenone (22877-01-6) → 2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate (1292298-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: phenyltrimethylammonium tribromide / methanol; dichloromethane / 20 °C

2: potassium carbonate / acetonitrile / 20 °C

With phenyltrimethylammonium tribromide; potassium carbonate; In methanol; dichloromethane; acetonitrile;

DOI:10.1139/V10-143

Reference yield: 97.0%

2-(2,4-bis(benzyloxy)phenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate (1292298-98-6) → 2-(2,4-dihydroxyphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate (1292298-99-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃;

DOI:10.1139/V10-143

upstream raw materials:

1-[2,4-bis(benzyloxy)phenyl]-2-bromoethan-1-one

N-(tert-butoxycarbonyl)-4-aminobutanoic acid

2,4-bis(benzyloxy)acetophenone

Downstream raw materials:

2-(2,4-dihydroxyphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate

4-(2-(2,4-dihydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate

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