(5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol

Base Information

Chemical Name:(5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol
CAS No.:1381767-11-8
Molecular Formula:C₁₈H₁₄F₃NO₃S
Molecular Weight:381.375
Hs Code.:

Synonyms:(5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol

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Chemical Property of (5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol

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Technology Process of (5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol

There total 3 articles about (5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 881673-48-9
ethyl 5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrole-3-carboxylate

: 1381767-11-8
(5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol

Guidance literature:: ethyl 5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrole-3-carboxylate; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; toluene;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 22984-74-3
Ethyl 2-cyano-4-oxo-4-phenylbutanoate

: 1381767-11-8
(5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 1 h / 0 - 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 158692-57-0
Ethyl 2-chloro-5-phenyl-1H-pyrrole-3-carboxylate

: 1381767-11-8
(5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 1 h / 0 - 20 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1016/j.bmc.2012.04.014