N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride

Base Information

Chemical Name:N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride
CAS No.:1381767-22-1
Molecular Formula:C₂₀H₁₉F₃N₂O₂S*ClH
Molecular Weight:444.905
Hs Code.:

Synonyms:N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride

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Chemical Property of N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride

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Technology Process of N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride

There total 9 articles about N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₇F₃N₂O₂S

: 1381767-22-1
N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride

Guidance literature:: C₂₀H₁₇F₃N₂O₂S; With sodium tetrahydroborate; In methanol; ethanol; at 20 ℃; for 1.5h;

With hydrogenchloride; In ethyl acetate;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 1381767-14-1
1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]sulfonyl}-1H-pyrrol-3-yl)ethanone

: 1381767-22-1
N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; ethanol / 1.5 h / 70 °C / Molecular sieve

2: sodium tetrahydroborate / methanol; ethanol / 1.5 h / 20 °C

With sodium tetrahydroborate; In methanol; ethanol;
DOI:10.1016/j.bmc.2012.04.014

Reference yield:

: 22984-74-3
Ethyl 2-cyano-4-oxo-4-phenylbutanoate

: 1381767-22-1
N-methyl-1-(5-phenyl-1-{[4-(trifluoromethyl)phenyl]-sulfonyl}-1H-pyrrol-3-yl)ethanamine hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / tetrahydrofuran / 3 h / 20 °C / Cooling with ice

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 1 h / 0 - 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.5 h / -78 °C

5.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 1 h / 20 °C / Molecular sieve

6.1: tetrahydrofuran; diethyl ether / 1 h / 10 °C

7.1: manganese(IV) oxide / dichloromethane / 4 h / 20 °C

8.1: methanol; ethanol / 1.5 h / 70 °C / Molecular sieve

9.1: sodium tetrahydroborate / methanol; ethanol / 1.5 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.04.014