5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Base Information

• Chemical Name: 5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one
• CAS No.: 660396-69-0
• Molecular Formula: C₃₇H₄₁NO₈
• Molecular Weight: 627.734
• Mol file: 660396-69-0.mol

Synonyms:5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Chemical Property of 5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

There total 29 articles about 5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

7-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one (875654-30-1) → 5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one (660396-69-0)

Guidance literature:

With boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at -40 ℃; for 1.5h;

DOI:10.1016/j.tet.2005.10.014

Reference yield: 65.0%

3,4-dihydro-7-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid (875654-43-6) → 7-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one (875654-30-1) + 5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one (660396-69-0)

Guidance literature:

palladium diacetate; In acetonitrile; for 12h; Heating;

DOI:10.1016/j.tet.2005.10.014

Reference yield: 47.0%

6-isopropoxy-7-methoxy-3,4-dihydroisoquinoline + iodoacetic acid 5-isopropoxy-2-(4-isopropoxy-3-methoxy-phenylethynyl)-4-methoxy-phenyl ester (200941-19-1) → 5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one (660396-69-0)

Guidance literature:

6-isopropoxy-7-methoxy-3,4-dihydroisoquinoline; iodoacetic acid 5-isopropoxy-2-(4-isopropoxy-3-methoxy-phenylethynyl)-4-methoxy-phenyl ester; In 1,2-dichloro-ethane; at 23 ℃; for 8h;

With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 85 ℃; for 32h;

DOI:10.1016/j.bmc.2004.01.020

upstream raw materials:

7-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-4(3H)-one

3,4-dihydro-7-isopropoxy-1-(4-isopropoxy-3-methoxyphenyl)-3-[2-(3-isopropoxy-4-methoxyphenyl)ethyl]-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrole-2-carboxylic acid

iodoacetic acid 5-isopropoxy-2-(4-isopropoxy-3-methoxy-phenylethynyl)-4-methoxy-phenyl ester

2-isopropoxy-1-methoxy-4-methoxymethoxybenzene

Downstream raw materials:

14-(3,4-dihydroxyphenyl)-2,3,11,12-tetrahydroxy-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]isoquinolin-6-one

14-(4-acetoxy-3-methoxyphenyl)-3,11-diacetoxy-2,12-dimethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

C₇₀H₇₄N₄O₁₇

6-tert-butoxycarbonylamino-hexanoic acid 10-(6-tert-butoxycarbonylamino-hexanoyloxy)-13-[4-(6-tert-butoxycarbonylamino-hexanoyloxy)-3-methoxy-phenyl]-2,11-dimethoxy-6-oxo-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester