(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate

Base Information

Chemical Name:(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate
CAS No.:1308835-55-3
Molecular Formula:C₆H₈O₇*C₁₅H₁₄Cl₂FN₃O₂
Molecular Weight:550.325
Hs Code.:

Synonyms:(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate

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Chemical Property of (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate

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Technology Process of (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate

There total 5 articles about (1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308835-53-1
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide

: 77-92-9,906507-37-7
citric acid

: 1308835-55-3
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate

Guidance literature:: In acetic acid; at 26 - 27 ℃; for 15.8333h; Product distribution / selectivity;

Reference yield:

: 748780-77-0
3,4-dichlorobenzyl-2,2,2-trichloroacetoimidate

: 1308835-55-3
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluorormethanesulfonic acid / TETRAHYDROPYRANE / 1.75 h / 24 - 31 °C

2.1: ammonia / methanol / 1.15 h / 17 - 25 °C / Inert atmosphere

2.2: 4.63 h / 0 - 25 °C

2.3: 20.58 h / -6 - 0 °C

3.1: acetic acid / 15.83 h / 26 - 27 °C

With trifluorormethanesulfonic acid; ammonia; In TETRAHYDROPYRANE; methanol; acetic acid;

Reference yield:

: 1308835-40-6
ethyl (1R,3R,5R,6R)-6-fluoro-3-hydroxy-2-oxo bicyclo[3.1.0]hexane-6-carboxylate

: 1308835-55-3
(1R,2S,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluoro bicyclo[3.1.0]hexane-6-carboxamide citrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluorormethanesulfonic acid / TETRAHYDROPYRANE / 1.75 h / 24 - 31 °C

2.1: ammonia / methanol / 1.15 h / 17 - 25 °C / Inert atmosphere

2.2: 4.63 h / 0 - 25 °C

2.3: 20.58 h / -6 - 0 °C

3.1: acetic acid / 15.83 h / 26 - 27 °C

With trifluorormethanesulfonic acid; ammonia; In TETRAHYDROPYRANE; methanol; acetic acid;