Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Base Information

Chemical Name:Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate
CAS No.:1059701-65-3
Molecular Formula:C₄₀H₅₁N₃O₅
Molecular Weight:653.862
Hs Code.:

Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Synonyms:Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

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Chemical Property of Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

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Technology Process of Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

There total 4 articles about Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1059701-50-6
tert-butyl (1aR,12bS)-8-cyclohexyl-1a-(2,5-diazabicyclo[2.2.2]oct-2-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

: 6482-24-2
2-Bromoethyl methyl ether

: 1059701-65-3
Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 70 ℃; for 20h;

Reference yield:

: 1033906-79-4
5-tert-butyl 1a-ethyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1,12b-dihydrocyclopropa[d]indolo[2,1-a][2]benzazepine-1a,5(2H)-dicarboxylate

: 1059701-65-3
Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3.33 h / 0 - 20 °C

1.2: 0 °C / pH <= 4

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C

3.1: potassium carbonate / tetrahydrofuran / 20 h / 70 °C

With sodium hydroxide; water; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1059700-79-6
(4bR,5aS)-9-(tert-butoxycarbonyl)-12-cyclohexyl-3-methoxy-4b,5,5a,6-tetrahydrobenzo[3,4]cyclopropa[5,6]azepino-[1,2-a]indole-5a-carboxylic acid

: 1059701-65-3
Tert-butyl (1aR,12bS)-8-cyclohexyl-11-methoxy-1a-((5-(2-methoxyethyl)-2,5-diazabicyclo[2.2.2]oct-2-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 °C

2: potassium carbonate / tetrahydrofuran / 20 h / 70 °C

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;