(R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide

Base Information

Chemical Name:(R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide
CAS No.:1434271-75-6
Molecular Formula:C₂₁H₁₉BrN₂O₃
Molecular Weight:427.297
Hs Code.:

Synonyms:(R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide

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Technology Process of (R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide

There total 6 articles about (R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 23200-93-3
3-methoxypyridazine 1-oxide

: 1354810-21-1
(R)-3-(4-bromo-phenyl)-N-methoxy-N-methyl-3-o-tolyl-propionamide

: 1434271-75-6
(R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1434271-75-6
(R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine / toluene / 5 h / Dean-Stark; Reflux

2: toluene; tetrahydrofuran / 2.83 h / 0 - 85 °C

3: sulfuric acid; acetic acid / 20.5 h / 27 °C / Cooling with ice; Reflux

4: 1,1'-carbonyldiimidazole / dichloromethane / 17 h / 20 °C

5: chiral HPLC (Reprosil Chiral-NR, heptane/2-propanol 80:20) / n-heptane; isopropyl alcohol / Resolution of racemate

6: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -70 °C

With piperidine; 2,2,6,6-tetramethyl-piperidine; n-butyllithium; sulfuric acid; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; hexane; n-heptane; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 1354808-43-7
3-(4-bromophenyl)-3-o-tolylpropanoic acid

: 1434271-75-6
(R)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine-1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 1,1'-carbonyldiimidazole / dichloromethane / 17 h / 20 °C

2: chiral HPLC (Reprosil Chiral-NR, heptane/2-propanol 80:20) / n-heptane; isopropyl alcohol / Resolution of racemate

3: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -70 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; 1,1'-carbonyldiimidazole; In tetrahydrofuran; hexane; n-heptane; dichloromethane; isopropyl alcohol;