N-benzyloxycarbonyl-D-phenylalanyl-N^α-methyl-L-lysyl(N^ε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride

Base Information

• Chemical Name: N-benzyloxycarbonyl-D-phenylalanyl-N^α-methyl-L-lysyl(N^ε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride
• CAS No.: 128718-88-7
• Molecular Formula: C₄₃H₅₆N₆O₇*ClH
• Molecular Weight: 805.415

Synonyms:N-benzyloxycarbonyl-D-phenylalanyl-N^α-methyl-L-lysyl(N^ε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride

Chemical Property of N-benzyloxycarbonyl-D-phenylalanyl-N^α-methyl-L-lysyl(N^ε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride

Chemical Property:

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Technology Process of N-benzyloxycarbonyl-D-phenylalanyl-N^α-methyl-L-lysyl(N^ε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride

There total 11 articles about N-benzyloxycarbonyl-D-phenylalanyl-N^α-methyl-L-lysyl(N^ε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

N-benzyloxycarbonyl-D-phenylalanyl-Nα-methyl-L-lysyl(Nε-Me,Boc)-D-tryptophyl-L-leucine methyl ester (128719-79-9) → N-benzyloxycarbonyl-D-phenylalanyl-Nα-methyl-L-lysyl(Nε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride (128718-88-7)

Guidance literature:

With hydrogenchloride; In acetic acid; for 1.5h; Ambient temperature;

Reference yield:

Cbz-D-Phe (2448-45-5) → N-benzyloxycarbonyl-D-phenylalanyl-Nα-methyl-L-lysyl(Nε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride (128718-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine / dimethylformamide / 0.03 h

2: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

3: 99.3 percent / 3N HCl / acetic acid / 1.5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; triethylamine; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) → N-benzyloxycarbonyl-D-phenylalanyl-Nα-methyl-L-lysyl(Nε-Me)-D-tryptophyl-L-leucine methyl ester hydrochloride (128718-88-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) NaH

2: 73 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

3: H₂, glacial acetic acid / 5percent Pd/C

4: Et₃N / dimethylformamide / 1.) -10 deg C, 30 min, 2.) 4 deg C, 2 h

5: 99.3 percent / 3N HCl / acetic acid / 1.5 h / Ambient temperature

With hydrogenchloride; hydrogen; sodium hydride; benzotriazol-1-ol; acetic acid; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

N-benzyloxycarbonyl-D-phenylalanyl-N^α-methyl-L-lysyl(N^ε-Me,Boc)-D-tryptophyl-L-leucine methyl ester

Z-Lys(Boc)-OH

Cbz-D-Phe

methyl (L)-leucinate hydrochloride

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