4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid

Base Information

Chemical Name:4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid
CAS No.:1202042-05-4
Molecular Formula:C₁₂H₄Cl₂INO₂S
Molecular Weight:424.046
Hs Code.:

Synonyms:4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid

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Chemical Property of 4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid

Chemical Property:

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Technology Process of 4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid

There total 7 articles about 4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202042-04-3
ethyl 4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylate

: 1202042-05-4
4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid

Guidance literature:: ethyl 4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylate; With water; sodium hydroxide; In tetrahydrofuran;

With hydrogenchloride; In tetrahydrofuran; water; Product distribution / selectivity;

Reference yield:

: 4-cyano-3-iodo-5-(methylthio)thiophene-2-carboxylic acid ethyl ester

: 1202042-05-4
4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran; dichloromethane / 20 °C

2: tetrahydrofuran / 72 h / 60 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

5: diiodomethane; isopentyl nitrite / acetonitrile / 20 - 38 °C / Inert atmosphere

6: water; sodium hydroxide / tetrahydrofuran

With diiodomethane; water; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 3: Suzuki Coupling / 5: Sandmeyer Reaction;

Reference yield:

: 861966-15-6
4-cyano-3-iodo-5-methanesulfonylthiophene-2-carboxylic acid ethyl ester

: 1202042-05-4
4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 72 h / 60 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

4: diiodomethane; isopentyl nitrite / acetonitrile / 20 - 38 °C / Inert atmosphere

5: water; sodium hydroxide / tetrahydrofuran

With diiodomethane; water; sodium carbonate; trifluoroacetic acid; sodium hydroxide; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 2: Suzuki Coupling / 4: Sandmeyer Reaction;