4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Base Information

Chemical Name:4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile
CAS No.:1202042-07-6
Molecular Formula:C₁₃H₅Cl₂IN₄S
Molecular Weight:447.086
Hs Code.:

Synonyms:4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

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Chemical Property of 4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

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Technology Process of 4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

There total 11 articles about 4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1202042-06-5
4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1202042-07-6
4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Guidance literature:: 4-cyano-3-(2,4-dichlorophenyl)-5-iodothiophene-2-carboxylamide; N,N-dimethyl-formamide dimethyl acetal; at 120 ℃; for 0.5h; Microwave irradiation;

With hydrazine hydrate; acetic acid; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: C₁₅H₁₀Cl₂IN₃OS

: 1202042-07-6
4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Guidance literature:: With hydrazine hydrate; acetic acid; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 4-cyano-3-iodo-5-(methylthio)thiophene-2-carboxylic acid ethyl ester

: 1202042-07-6
4-(2,4-dichlorophenyl)-2-iodo-5-(4H-1,2,4-triazol-3-yl)thiophene-3-carbonitrile

Guidance literature:: Multi-step reaction with 9 steps

1.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran; dichloromethane / 20 °C

2.1: tetrahydrofuran / 72 h / 60 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.17 h / 140 °C / Microwave irradiation; Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.17 h / 20 °C

5.1: diiodomethane; isopentyl nitrite / acetonitrile / 20 - 38 °C / Inert atmosphere

6.1: water; sodium hydroxide / tetrahydrofuran

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h

7.2: 2 h

8.1: 0.5 h / 120 °C / Microwave irradiation

9.1: hydrazine hydrate; acetic acid / 0.25 h / 120 °C / Microwave irradiation

With diiodomethane; water; sodium carbonate; benzotriazol-1-ol; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 3.1: Suzuki Coupling / 5.1: Sandmeyer Reaction;