Technology Process of (+)-(S)-3-Benzyl-2-oxetanone
There total 7 articles about (+)-(S)-3-Benzyl-2-oxetanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dimethyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 5h;
DOI:10.1016/S0968-0896(02)00108-6
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 73 percent / Jones' reagent / acetone
2.1: 90 percent / methanol; K2CO3; water / 2 h / 20 °C
3.1: 86 percent / acetyl chloride / 24 h / 20 °C
4.1: phosphate buffer; α-chymotrypsin; sodium hydroxide / 18 h / pH 7.5 / Enzymatic reaction
4.2: SOCl2
5.1: 70 percent / LiOH / tetrahydrofuran; methanol / 12 h / 20 °C
6.1: 75 percent / triphenylphosphine; dimethyl azodicarboxylate / tetrahydrofuran / 5 h / -78 - 20 °C
With
methanol; lithium hydroxide; sodium hydroxide; jones' reagent; phosphate buffer; water; potassium carbonate; dimethyl azodicarboxylate; acetyl chloride; triphenylphosphine; α-chymotrypsin;
In
tetrahydrofuran; methanol; acetone;
6.1: Mitsunobu reaction;
DOI:10.1016/S0968-0896(02)00108-6
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 90 percent / methanol; K2CO3; water / 2 h / 20 °C
2.1: 86 percent / acetyl chloride / 24 h / 20 °C
3.1: phosphate buffer; α-chymotrypsin; sodium hydroxide / 18 h / pH 7.5 / Enzymatic reaction
3.2: SOCl2
4.1: 70 percent / LiOH / tetrahydrofuran; methanol / 12 h / 20 °C
5.1: 75 percent / triphenylphosphine; dimethyl azodicarboxylate / tetrahydrofuran / 5 h / -78 - 20 °C
With
methanol; lithium hydroxide; sodium hydroxide; phosphate buffer; water; potassium carbonate; dimethyl azodicarboxylate; acetyl chloride; triphenylphosphine; α-chymotrypsin;
In
tetrahydrofuran; methanol;
5.1: Mitsunobu reaction;
DOI:10.1016/S0968-0896(02)00108-6
