N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid

Base Information

Chemical Name:N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid
CAS No.:1345532-71-9
Molecular Formula:C₂₇H₄₅N₅O₆
Molecular Weight:535.684
Hs Code.:

Synonyms:N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid

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Chemical Property of N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid

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Technology Process of N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid

There total 5 articles about N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345532-70-8
C₃₆H₆₁N₅O₈

: 1345532-71-9
N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid

Guidance literature:: C₃₆H₆₁N₅O₈; With trifluoroacetic acid; for 1h;

With hydrogenchloride; In acetonitrile;

Reference yield:

: 1221593-55-0
{(S)-5-amino-5-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

: 1345532-71-9
N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 5 - 20 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 1.5 h / 3620.13 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / Sonication

3.2: 2 h / 5 - 20 °C

4.1: trifluoroacetic acid / 1 h

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1221593-54-9
{(S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-pentyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 1345532-71-9
N-[(S)-5-amino-1-(2-([3-((1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenoxycarbonyl]-methyl-amino)-ethylcarbamoyl)-penlyl]-malonamic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine / ethyl acetate / 3 h / 20 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 5 - 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 1.5 h / 3620.13 Torr

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / Sonication

4.2: 2 h / 5 - 20 °C

5.1: trifluoroacetic acid / 1 h

With piperidine; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;