N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester

Base Information

Chemical Name:N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester
CAS No.:1345532-68-4
Molecular Formula:C₂₉H₄₆N₄O₈
Molecular Weight:578.706
Hs Code.:

Synonyms:N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester

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Chemical Property of N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester

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Technology Process of N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester

There total 2 articles about N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40052-13-9
mono-tert-butyl malonate

: 1221593-55-0
{(S)-5-amino-5-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester

: 1345532-68-4
N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 5 - 20 ℃; for 2h;

Reference yield:

: 1221593-54-9
{(S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-pentyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 1345532-68-4
N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / ethyl acetate / 3 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 5 - 20 °C

With piperidine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1345532-68-4
N-((S)-1-[2-(benzyloxycarbonyl-methyl-amino)-ethylcarbamoyl]-5-tert-butoxycarbonylamino-penlyl)-malonamic acid tert-butyl ester

: 1345532-70-8
C₃₆H₆₁N₅O₈

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / 5%-palladium/activated carbon / methanol / 1.5 h / 3620.13 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / Sonication

2.2: 2 h / 5 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In methanol; dichloromethane;