(2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

Base Information

Chemical Name:(2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester
CAS No.:195302-01-3
Molecular Formula:C₂₈H₃₉N₅O₁₀
Molecular Weight:605.645
Hs Code.:

Synonyms:(2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

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Chemical Property of (2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

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Technology Process of (2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

There total 6 articles about (2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 368443-70-3
(2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

: 195302-01-3
(2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 0.75h;
DOI:10.1039/b100401h

Reference yield:

: 175452-89-8
α-methyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate ester

: 195302-01-3
(2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / aq. K₂CO₃ / diethyl ether / 1 h / 0 °C

2: 72 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂

3: 83 percent / piperidine / dimethylformamide / 0.75 h / 20 °C

With piperidine; phenylsilane; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b100401h

Reference yield:

: 368443-68-9
α-methyl γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate

: 195302-01-3
(2S)-phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] diester

Guidance literature:: Multi-step reaction with 5 steps

1: 81 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂ / 2 h / 20 °C

2: 100 percent / aq. K₂CO₃ / diethyl ether / 1 h / 0 °C

3: 72 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂

4: 83 percent / piperidine / dimethylformamide / 0.75 h / 20 °C

With piperidine; phenylsilane; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b100401h