(2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

Base Information

Chemical Name:(2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]
CAS No.:368443-70-3
Molecular Formula:C₄₃H₄₉N₅O₁₂
Molecular Weight:827.888
Hs Code.:

Synonyms:(2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

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Chemical Property of (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

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Technology Process of (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

There total 5 articles about (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 195302-00-2
β-allyl (2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartate] triester

: 368443-70-3
(2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

Guidance literature:: With phenylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane;
DOI:10.1039/b100401h

Reference yield:

: 175452-89-8
α-methyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate ester

: 368443-70-3
(2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. K₂CO₃ / diethyl ether / 1 h / 0 °C

2: 72 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂

With phenylsilane; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane;
DOI:10.1039/b100401h

Reference yield:

: 368443-68-9
α-methyl γ-allyl (2R)-N-(fluoren-9-ylmethoxycarbonyl)glutamate

: 368443-70-3
(2S)-N-(fluoren-9-ylmethoxycarbonyl)phenylalanyl-β-alanyl-[α-methyl (2R)-glutamyl]-γ-(2S)-prolyl-[α-methyl (2R)-aspartic acid]

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂ / 2 h / 20 °C

2: 100 percent / aq. K₂CO₃ / diethyl ether / 1 h / 0 °C

3: 72 percent / PhSiH₃ / (Ph₃P)4Pd⁽⁰⁾ / CH₂Cl₂

With phenylsilane; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; dichloromethane;
DOI:10.1039/b100401h