(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Base Information

Chemical Name:(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone
CAS No.:158705-72-7
Molecular Formula:C₂₇H₂₆O₆
Molecular Weight:446.5
Hs Code.:

Synonyms:(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

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Chemical Property of (3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

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Technology Process of (3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

There total 6 articles about (3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 158665-03-3
(3R,4R,5R)-4-<1,3-Benzodioxol-5-ylbis(phenylthio)methyl>-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>-5-(l-menthyloxy)dihydro-2(3H)-furanone

: 158705-72-7
(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Guidance literature:: With potassium hydroxide; sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; methanol;
DOI:10.1021/jo00099a033

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 158705-72-7
(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / AlCl₃ / CH₂Cl₂ / 2 h

2: 1.) n-BuLi, 2.) TMEDA / 1.) THF, hexane, -20 deg C, 90 min; -80 deg C, 2 h, 2.) -20 deg C, 16 h

3: 62 percent / NiCl₂*6H₂O, NaBH₄, 2 N aq. KOH / tetrahydrofuran; methanol

With potassium hydroxide; sodium tetrahydroborate; n-butyllithium; aluminium trichloride; N,N,N,N,-tetramethylethylenediamine; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00099a033

Reference yield:

: 2426-87-1
3-methoxy-4-(phenylmethoxy)benzaldehyde

: 158705-72-7
(3R,4R)-4-(1,3-Benzodioxol-5-ylmethyl)-3-<(4-(benzyloxy)-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₄ / methanol; CH₂Cl₂ / 1 h

2: PBr₃ / diethyl ether / 3 h / Ambient temperature

3: 1.) n-BuLi, 2.) TMEDA / 1.) THF, hexane, -20 deg C, 90 min; -80 deg C, 2 h, 2.) -20 deg C, 16 h

4: 62 percent / NiCl₂*6H₂O, NaBH₄, 2 N aq. KOH / tetrahydrofuran; methanol

With potassium hydroxide; sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; phosphorus tribromide; nickel dichloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00099a033