1-Phenylpiperidin-4-ol

Base Information

• Chemical Name: 1-Phenylpiperidin-4-ol
• CAS No.: 117896-69-2
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90371877
• Wikidata: Q82159385
• Mol file: 117896-69-2.mol

Synonyms:1-phenylpiperidin-4-ol;117896-69-2;1-phenyl-4-piperidinol;4-Piperidinol,1-phenyl-;4-Piperidinol, 1-phenyl-;1-phenyl-4-hydroxypiperidine;phenyl-4-piperidol;1-phenylpiperidin-4-ol';N-phenyl-4-hydroxypiperidine;4-hydroxy-1-phenylpiperidine;SCHEMBL3537362;AMY6026;DTXSID90371877;MFCD02093533;AKOS015908909;SB41205;BS-14436;CS-0069832;F13286;F2167-0835

Chemical Property of 1-Phenylpiperidin-4-ol

Chemical Property:

• Vapor Pressure: 0.000204mmHg at 25°C
• Melting Point: 69-70℃
• Refractive Index: 1.577
• Boiling Point: 314 °C at 760 mmHg
• PKA: 14.90±0.20(Predicted)
• Flash Point: 160.9 °C
• PSA: 23.47000
• Density: 1.116 g/cm³
• LogP: 1.71270
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 146

Purity/Quality:

97% ^*data from raw suppliers

1-Phenylpiperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1O)C2=CC=CC=C2

Technology Process of 1-Phenylpiperidin-4-ol

There total 14 articles about 1-Phenylpiperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(1-(4-methoxyphenyl)but-3-enyl)benzenamine → 1-phenyl-4-hydroxypiperidine (117896-69-2)

Guidance literature:

With trifluoroacetic acid; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1002/ejoc.201403607

Reference yield: 68.21%

4-HYDROXYPIPERIDINE (5382-16-1) + iodobenzene (591-50-4) → 1-phenyl-4-hydroxypiperidine (117896-69-2)

Guidance literature:

With copper(l) iodide; 2-acetylcyclohexanone; caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 48h;

Reference yield: 50.0%

But-3-enyl-tert-butylperoxymethyl-phenyl-amine (117896-64-7) → 1-phenyl-4-hydroxypiperidine (117896-69-2)

Guidance literature:

With trifluoroacetic acid; In diethyl ether; Ambient temperature;

DOI:10.1021/ja00232a060

upstream raw materials:

But-3-enyl-tert-butylperoxymethyl-phenyl-amine

1,5-Dichloropentan-3-ol

aniline

1-phenylpiperidin-4-one

Downstream raw materials:

4-bromo-1-phenyl-piperidine

C₁₆H₂₃NO₂

methyl N-tert-butoxycarbonyl-O-(1-phenyl-piperidin-4-yl)-L-tyrosinate

4-Methoxy-1-phenyl-1,2,5,6-tetrahydropyridine