1-N-PHENYL-PIPERIDIN-4-ONE

Base Information

• Chemical Name: 1-N-PHENYL-PIPERIDIN-4-ONE
• CAS No.: 19125-34-9
• Molecular Formula: C11H13 N O
• Molecular Weight: 175.23
• Mol file: 19125-34-9.mol

Synonyms:4-Piperidone,1-phenyl- (7CI,8CI); 1-Phenyl-4-piperidinone; 1-Phenyl-4-piperidone;N-Phenyl-4-piperidone

Chemical Property of 1-N-PHENYL-PIPERIDIN-4-ONE

Chemical Property:

• Vapor Pressure: 1.45E-05mmHg at 25°C
• Melting Point: 36.5-37.2℃
• Refractive Index: 1.56
• Boiling Point: 312.9°Cat760mmHg
• Flash Point: 124.1°C
• PSA: 17.07000
• Density: 1.107g/cm³
• LogP: 2.91330
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Phenylpiperidin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Phenylpiperidin-4-one is a reagent used in the preparation of isoteric N-arylpiperazine as dihydropyridine NPY1 receptor antagonists.

Technology Process of 1-N-PHENYL-PIPERIDIN-4-ONE

There total 26 articles about 1-N-PHENYL-PIPERIDIN-4-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

8-phenyl-1,4-dioxa-8-azaspiro[4,5]decane (198649-62-6) → 1-phenylpiperidin-4-one (19125-34-9)

Guidance literature:

8-phenyl-1,4-dioxa-8-azaspiro[4.5]decane; With hydrogenchloride; In ethanol; water; for 5h; Reflux;

With sodium hydrogencarbonate; In ethanol; water;

Reference yield: 99.0%

1-Phenyl-4,4-dimethoxypiperidine (188252-72-4) → 1-phenylpiperidin-4-one (19125-34-9)

Guidance literature:

With formic acid; for 2h; Ambient temperature;

DOI:10.1039/a606191e

Reference yield: 89.2%

1-phenyl-4-hydroxypiperidine (117896-69-2) → 1-phenylpiperidin-4-one (19125-34-9)

Guidance literature:

With chromium(VI) oxide; In toluene; at 70 ℃; Temperature;

upstream raw materials:

4-oxo-1-phenyl-piperidine-3-carboxylic acid ethyl ester

1,5-dichloropentan-3-one

aniline

1-Phenyl-4,4-dimethoxypiperidine

Downstream raw materials:

1-phenyl-hexahydro-[1,4]diazepin-5-one

N,N-di(prop-2-yn-1-yl)aniline

1-phenyl-4-(carboethoxymethylene)piperidine

2-(1-phenylpiperidin-4-ylidene)acetonitrile