2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide

Base Information

Chemical Name:2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide
CAS No.:1061377-25-0
Molecular Formula:C₂₂H₂₆N₂O₅
Molecular Weight:398.459
Hs Code.:

Synonyms:2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide

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Chemical Property of 2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide

Chemical Property:

Purity/Quality:

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Technology Process of 2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide

There total 6 articles about 2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 925920-62-3
3-[3-(morpholino)propoxy]benzenamine

: 2861-28-1
1,3-benzodioxole-5-acetic acid

: 1061377-25-0
2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 19h;
DOI:10.1016/j.bmcl.2009.05.102

Reference yield:

: 1061378-23-1
tert-butyl 3-(3-morpholinopropoxy)phenylcarbamate

: 1061377-25-0
2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; phosphoric acid; water / 2.5 - 12 h / 20 °C

1.2: 0 °C / pH >= 12

2.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 96 h / 20 °C

With hydrogenchloride; dmap; phosphoric acid; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform;

Reference yield:

: 4441-30-9
3-morpholin-4-ylpropan-1-ol

: 1061377-25-0
2-(benzo[d][1,3]dioxol-5-yl)-N-(3-(3-morpholinopropoxy)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 3.25 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 24 - 72 h / 55 °C

3.1: hydrogenchloride; phosphoric acid; water / 2.5 - 12 h / 20 °C

3.2: 0 °C / pH >= 12

4.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / chloroform / 96 h / 20 °C

With hydrogenchloride; dmap; phosphoric acid; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; chloroform; N,N-dimethyl-formamide;