N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

Base Information

Chemical Name:N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester
CAS No.:223923-56-6
Molecular Formula:C₂₈H₄₆N₂O₈Si
Molecular Weight:566.767
Hs Code.:

Synonyms:N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

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Technology Process of N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

There total 3 articles about N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 223923-54-4
(2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

: N-Boc-D-glutamate α-methyl ester hydrochloride

: 223923-56-6
N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; Ambient temperature;
DOI:10.1021/jo982145i

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 223923-56-6
N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / DCC / tetrahydrofuran / 36 h / Ambient temperature

2: 86 percent / BOP / CH₂Cl₂ / Ambient temperature

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo982145i

Reference yield:

: 64263-80-5
N-Boc-N-methyl-O-benzyl-L-threonine

: 223923-56-6
N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / DCC / tetrahydrofuran / 36 h / Ambient temperature

2: 86 percent / BOP / CH₂Cl₂ / Ambient temperature

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo982145i