(2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

Base Information

Chemical Name:(2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester
CAS No.:223923-54-4
Molecular Formula:C₂₂H₃₇NO₅Si
Molecular Weight:423.625
Hs Code.:

Synonyms:(2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

Chemical Property:

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Technology Process of (2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

There total 2 articles about (2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 64263-80-5
N-Boc-N-methyl-O-benzyl-L-threonine

: 223923-54-4
(2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

Guidance literature:: With pyridine; dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1039/cc9960001683

Reference yield:

: 15260-10-3
N-Boc-O-benzyl-L-threonine

: 223923-54-4
(2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / NaH / tetrahydrofuran

2: 65 percent / DCC, DMAP, pyridine / CH₂Cl₂

With pyridine; dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/cc9960001683

Reference yield: 86.0%

: 223923-54-4
(2S,3R)-N-Boc-N-methyl-O-benzyl-L-threonine trimethylsilyl ester

: N-Boc-D-glutamate α-methyl ester hydrochloride

: 223923-56-6
N-Boc-D-γ-glutamyl-(α-methyl ester)-N-methyl-O-benzyl-L-threonine trimethylsilylethyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; Ambient temperature;
DOI:10.1021/jo982145i