4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID

Base Information

• Chemical Name: 4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID
• CAS No.: 486422-58-6
• Molecular Formula: C₁₁H₁₆BNO₄S
• Molecular Weight: 269.129
• Hs Code.: 2935009090
• Mol file: 486422-58-6.mol

Synonyms:Boronicacid, [4-(1-piperidinylsulfonyl)phenyl]- (9CI);4-(Piperidin-1-ylsulfonyl)benzeneboronic acid; [4-((Piperidin-1-yl)sulfonyl)phenyl]boronicacid

Chemical Property of 4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 1.11E-09mmHg at 25°C
• Melting Point: 268-272
• Boiling Point: 471.2°Cat760mmHg
• Flash Point: 238.8°C
• PSA: 86.22000
• Density: 1.37g/cm³
• LogP: 0.55970
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-(Piperidin-1-ylsulfonyl)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID

There total 5 articles about 4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromobenzenesulfonyl chloride (98-58-8) → (4-(piperidin-1-ylsulfonyl)phenyl) boronic acid (486422-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; 1,4-dioxane

2: n-butyllithium / tetrahydrofuran / 18 h / -78 - 20 °C / Inert atmosphere

3: water; silica gel / tetrahydrofuran

With n-butyllithium; water; silica gel; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm201724m

Reference yield:

piperidine (110-89-4) → (4-(piperidin-1-ylsulfonyl)phenyl) boronic acid (486422-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; 1,4-dioxane

2: n-butyllithium / tetrahydrofuran / 18 h / -78 - 20 °C / Inert atmosphere

3: water; silica gel / tetrahydrofuran

With n-butyllithium; water; silica gel; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm201724m

Reference yield:

1-((4-bromophenyl)sulfonyl)piperidine (834-66-2) → (4-(piperidin-1-ylsulfonyl)phenyl) boronic acid (486422-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / 18 h / -78 - 20 °C / Inert atmosphere

2: water; silica gel / tetrahydrofuran

With n-butyllithium; water; silica gel; In tetrahydrofuran;

DOI:10.1021/jm201724m

upstream raw materials:

4-bromobenzenesulfonyl chloride

1-((4-bromophenyl)sulfonyl)piperidine

piperidine

Downstream raw materials:

ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

{6-fluoro-3-methyl-4-[4-(piperidine-1-sulfonyl)-phenyl]-naphthalen-2-yl}-acetic acid methyl ester

{6-chloro-3-methyl-4-[4-(piperidine-1-sulfonyl)-phenyl]-naphthalen-2-yl}-acetic acid methyl ester

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