ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

Base Information

Chemical Name:ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate
CAS No.:1394375-43-9
Molecular Formula:C₁₉H₂₃NO₄S₂
Molecular Weight:393.528
Hs Code.:

Synonyms:ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

Suppliers and Price of ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

There total 3 articles about ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 486422-58-6
(4-(piperidin-1-ylsulfonyl)phenyl) boronic acid

: 203195-42-0
methyl 3-bromo-4-methylthiophene-2-carboxylate

: 141-78-6
ethyl acetate

: 1394375-43-9
ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

Guidance literature:: (4-(piperidin-1-ylsulfonyl)phenyl) boronic acid; methyl 3-bromo-4-methylthiophene-2-carboxylate; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 25 - 105 ℃; Inert atmosphere;

ethyl acetate; In hexane;

Reference yield: 62.0%

: 486422-58-6
(4-(piperidin-1-ylsulfonyl)phenyl) boronic acid

: 203195-42-0
methyl 3-bromo-4-methylthiophene-2-carboxylate

: 64-17-5
ethanol

: 1394375-43-9
ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 25 - 105 ℃; for 15h; Inert atmosphere; Sealed tube;

Reference yield:

: 85006-31-1
3-amino-4-methyl-2-thiophenecarboxylic acid methyl ester

: 1394375-43-9
ethyl 4-methyl-3-(4-(piperidin-1-ylsulfonyl)phenyl)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 4 h / 20 - 25 °C / Inert atmosphere

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol / 25 - 105 °C / Inert atmosphere

With tert.-butylnitrite; potassium carbonate; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; acetonitrile; 1: Sandmeyer Reaction / 2: Suzuki Coupling;