(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate

Base Information

Chemical Name:(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate
CAS No.:1567347-29-8
Molecular Formula:C₃₁H₂₄ClF₂N₃O₆S
Molecular Weight:640.064
Hs Code.:

Synonyms:(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate

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Chemical Property of (5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate

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Technology Process of (5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate

There total 2 articles about (5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.7%

: 1029872-54-5,918504-65-1
vemurafenib

: 35180-03-1
chloromethyl phenyl carbonate

: 1567347-29-8
(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate

Guidance literature:: With tetrabutylammomium bromide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1567347-29-8
(5-(4-chlorophenyl)-3-(2,6-difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)methyl phenyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 5 h / -20 - 20 °C

2: tetrabutylammomium bromide; triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With pyridine; tetrabutylammomium bromide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;