1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:342890-03-3
Molecular Formula:C₄₉H₅₄N₂O₈Si
Molecular Weight:827.062
Hs Code.:

1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

There total 9 articles about 1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: Acetic acid 3-((E)-2-{[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-diisopropyl-silanyl}-vinyl)-naphthalen-2-yl ester

: 342890-03-3
1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With cyanide on Amberlyst; In methanol;
DOI:10.1021/ja002370t

Reference yield:

: 92-44-4
2,3-naphthalenediol

: 342890-03-3
1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / Et₃N / acetonitrile / -20 °C

2: 89 percent / Et₃N / 2 h / 0 °C

3: 83 percent / tetrabutylammonium fluoride / CH₂Cl₂ / 1 h / 0 °C

4: 91 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

5: 84 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / dimethylformamide / 10 h / 90 °C

6: 86 percent / tetrabutylammonium fluoride / CH₂Cl₂ / 2 h / 20 °C

7: H₂PtCl₆ / diethyl ether; propan-2-ol / 3 h / 20 °C

8: 88 percent / diisopropylethylamine / tetrahydrofuran / 0 °C

9: 90 percent / cyanide on Amberlyst / methanol

With dihydrogen hexachloroplatinate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; cyanide on Amberlyst; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
DOI:10.1021/ja002370t

Reference yield:

: 342890-16-8
2-ethynyl-3-acetoxynaphthalene

: 342890-03-3
1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: H₂PtCl₆ / diethyl ether; propan-2-ol / 3 h / 20 °C

2: 88 percent / diisopropylethylamine / tetrahydrofuran / 0 °C

3: 90 percent / cyanide on Amberlyst / methanol

With dihydrogen hexachloroplatinate; cyanide on Amberlyst; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; isopropyl alcohol;
DOI:10.1021/ja002370t