Technology Process of ETM2
There total 8 articles about ETM2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Oxone;
In
N,N-dimethyl-formamide;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: palladium diacetate; caesium carbonate; tri-tert-butyl phosphine / toluene; 1,4-dioxane / 4 h / Reflux
2.1: tetrahydrofuran / 6 h / 5 °C
3.1: polyphosphoric acid / dichloromethane; methanesulfonic acid / -20 - 20 °C
4.1: sodium carbonate; bromine / water; dichloromethane / 6 h / 10 °C
5.1: n-butyllithium / diethyl ether / 3 h / 0 °C
5.2: 8 h / 20 °C
6.1: Oxone / N,N-dimethyl-formamide / 1 h
With
Oxone; n-butyllithium; tri-tert-butyl phosphine; bromine; palladium diacetate; sodium carbonate; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; methanesulfonic acid; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 6 h / 5 °C
2.1: polyphosphoric acid / dichloromethane; methanesulfonic acid / -20 - 20 °C
3.1: sodium carbonate; bromine / water; dichloromethane / 6 h / 10 °C
4.1: n-butyllithium / diethyl ether / 3 h / 0 °C
4.2: 8 h / 20 °C
5.1: Oxone / N,N-dimethyl-formamide / 1 h
With
Oxone; n-butyllithium; bromine; sodium carbonate;
In
tetrahydrofuran; methanesulfonic acid; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
