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534-85-0 Usage

Chemical Properties

White to Light yellow to Light red powder to crystal


N-Phenyl-o-phenylenediamine is also used as an intermediate in organic synthesis and pharmaceuticals.


The synthesis of 2-Aminodiphenylamine is as folliows:Reaction flask was added 0.108 g of o-phenylenediamine (1 mmol), phenylhydrazine0.216 g (2 mmol), CuPc 0.058 Ke (0.1 mmol), Cu (OAc) 2 0.02 g (0.1 mmol) and 10 ml ofacetonitrile, 15 °C reaction; TLC until the reaction was followed completely finished;the crude product after the reaction was subjected to column chromatography (petroleumether: ethyl acetate = 100: 1) to give the desired product (71% yield).


Keep container tightly closed. Store in cool, dry conditions in well sealed containers. It is sensitive to light. Store at room temperature. Incompatible with acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.

Purification Methods

Crystallise the amine from H2O. [Beilstein 13 IV 43.]

Check Digit Verification of cas no

The CAS Registry Mumber 534-85-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 534-85:
70 % 10 = 0
So 534-85-0 is a valid CAS Registry Number.

534-85-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L11616)  N-Phenyl-o-phenylenediamine, 98%   

  • 534-85-0

  • 5g

  • 244.0CNY

  • Detail
  • Alfa Aesar

  • (L11616)  N-Phenyl-o-phenylenediamine, 98%   

  • 534-85-0

  • 25g

  • 944.0CNY

  • Detail
  • Sigma-Aldrich

  • (07900)  N-Phenyl-o-phenylenediamine  purum, ≥98.0% (NT)

  • 534-85-0

  • 07900-25G

  • 1,230.84CNY

  • Detail
  • Aldrich

  • (P28352)  N-Phenyl-o-phenylenediamine  98%

  • 534-85-0

  • P28352-10G

  • 627.12CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name 2-Aminodiphenylamine

1.2 Other means of identification

Product number -
Other names mono-N-phenyl-o-phenylenediamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:534-85-0 SDS

534-85-0Relevant articles and documents

N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis


, (2020/12/02)

We present the design, synthesis and biological activity of novel N-substituted benzimidazole based acrylonitriles as potential tubulin polymerization inhibitors. Their synthesis was achieved using classical linear organic and microwave assisted techniques, starting from aromatic aldehydes and N-substituted-2-cyanomethylbenzimidazoles. All newly prepared compounds were tested for their antiproliferative activity in vitro on eight human cancer cell lines and one reference non-cancerous assay. N,N-dimethylamino substituted acrylonitriles 30 and 41, bearing N-isobutyl and cyano substituents placed on the benzimidazole nuclei, showed strong and selective antiproliferative activity in the submicromolar range of inhibitory concentrations (IC50 0.2–0.6 μM), while being significantly less toxic than reference systems docetaxel and staurosporine, thus promoting them as lead compounds. Mechanism of action studies demonstrated that two most active compounds inhibited tubulin polymerization. Computational analysis confirmed the suitability of the employed benzimidazole-acrylonitrile skeleton for the binding within the colchicine binding site in tubulin, thus rationalizing the observed antitumor activities, and demonstrated that E-isomers are active substances. It also provided structural determinants affecting both the binding position and the matching affinities, identifying the attached NMe2 group as the most dominant in promoting the binding, which allows ligands to optimize favourable cation???π and hydrogen bonding interactions with Lys352.

Biomimetic alloxan-catalyzed intramolecular redox reaction with O2: One-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles

Zhang, Shiqi,Yi, Dong,Li, Guangxun,Li, Ling,Zhao, Gang,Tang, Zhuo

supporting information, (2020/12/25)

Given the necessity of sacrificial reductants in various biomimetic aerobic oxygenations, alloxan-catalyzed aerobic redox system for one-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles was developed by ingeniously binding both the substrate sulfide and sacrificial reductant. This mild and transition-metal-free protocol undergoes two oxidations without additional sacrificial reagents, except for the environmentally benign molecular oxygen.

Fe-MIL-101 modified by isatin-Schiff-base-Co: a heterogeneous catalyst for C-C, C-O, C-N, and C-P cross coupling reactions

Farrokhi, Alireza,Rouzifar, Majid,Sansano, José Miguel,Sobhani, Sara

, p. 19963 - 19976 (2021/11/12)

A metal-organic framework functionalized with a cobalt-complex is preparedviapost-synthetic modification of Fe-MIL-101-NH2. Initially, Fe-MIL-101-NH2reacted with isatin to produce Fe-MIL-101-isatin-Schiff-base, which can anchor the cobalt by the addition of cobalt acetate. The resulting MOF-Co catalyst is characterized by employing multiple techniques. This new modified MOF acts as a heterogeneous and recyclable catalyst for efficient Ullmann, Buchwald-Hartwig, Hirao, Hiyama and Mizoroki-Heck cross-coupling reactions of several aryl halides/phenylboronic acid/phenyltosylate with phenols, anilines/heterocyclic amines, triethyl phosphite, triethoxyphenylsilane and alkenes and generates the expected coupling products in good to high yields.

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