(4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

Base Information

Chemical Name:(4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one
CAS No.:90741-76-7
Molecular Formula:C₄₆H₅₉NO₅SSi₂
Molecular Weight:794.215
Hs Code.:

(4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

Synonyms:(4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

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Chemical Property of (4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

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Technology Process of (4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

There total 7 articles about (4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2462-02-4
2-mercaptoacetophenone

: 90741-75-6,116205-93-7
(3S,3aR,4S,7S,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-7a-(2-chloro-acetyl)-4-methyl-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

: 90741-76-7,116205-94-8
(3S,3aR,4S,7S,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 17h;
DOI:10.1021/ja00167a036

Reference yield: 88.0%

: 2462-02-4
2-mercaptoacetophenone

: 90741-75-6
(4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-7a-(2-chloro-acetyl)-4-methyl-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

: 90741-76-7
(4R,7R,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

Guidance literature:: With potassium carbonate; In tetrahydrofuran;
DOI:10.1021/ja00328a053

Reference yield:

: 90741-74-5
(2E,4E,6Z)-1-(tert-Butyl-dimethyl-silanyloxy)-6-trimethylsilanylmethyl-octa-2,4,6-triene

: 90741-76-7,116205-94-8
(3S,3aR,4S,7S,7aS)-2-Benzoyl-3-benzyl-7-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-4-methyl-7a-[2-(2-oxo-2-phenyl-ethylsulfanyl)-acetyl]-5-trimethylsilanylmethyl-2,3,3a,4,7,7a-hexahydro-isoindol-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 0.17 h / Ambient temperature

2: 88 percent / K₂CO₃ / tetrahydrofuran / 17 h

With potassium carbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00167a036