(E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

Base Information

Chemical Name:(E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate
CAS No.:1252658-22-2
Molecular Formula:C₂₂H₃₀N₄O₄
Molecular Weight:414.505
Hs Code.:

Synonyms:(E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

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Chemical Property of (E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

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Technology Process of (E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

There total 5 articles about (E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1252658-21-1
3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-ol

: 96-32-2
bromoacetic acid methyl ester

: 1252658-22-2
(E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

Reference yield:

: 1252658-20-0
1-{[5-(benzyloxy)-1-methyl-1H-pyrazol-3-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

: 1252658-22-2
(E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / methanol / 3800.26 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1252658-19-7
methyl 5-(benzyloxy)-1-methyl-1H-pyrazole-3-carboxylate

: 1252658-22-2
(E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / tetrahydrofuran; methanol / 4 h / 40 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

3: hydrogen / palladium on activated charcoal / methanol / 3800.26 Torr

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

With hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;