[(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid

Base Information

Chemical Name:[(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid
CAS No.:1252657-72-9
Molecular Formula:C₂₁H₂₈N₄O₄
Molecular Weight:400.478
Hs Code.:

Synonyms:[(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid

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Chemical Property of [(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid

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Technology Process of [(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid

There total 6 articles about [(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1252658-22-2
(E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate

: 1252657-72-9
[(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid

Guidance literature:: (E) Methyl [(3-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetate; With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield:

: 1252658-20-0
1-{[5-(benzyloxy)-1-methyl-1H-pyrazol-3-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

: 1252657-72-9
[(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / methanol / 3800.26 Torr

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

With hydrogen; potassium carbonate; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1239775-52-0
5-(benzyloxy)-1-methyl-1H-pyrazole-3-carboxylic acid

: 1252657-72-9
[(3-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-1-methyl-1H-pyrazol-5-yl)oxy]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

2: hydrogen / palladium on activated charcoal / methanol / 3800.26 Torr

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

4: sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

With hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;