N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide
CAS No.:1244641-39-1
Molecular Formula:C₂₂H₁₈ClFN₄O₂S₂
Molecular Weight:488.994
Hs Code.:

Synonyms:N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide

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Chemical Property of N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide

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Technology Process of N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide

There total 6 articles about N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1195768-16-1
{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}amine

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1244641-39-1
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 4518-10-9
Methyl 3-aminobenzoate

: 1244641-39-1
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane

2: lithium hexamethyldisilazane

3: N-Bromosuccinimide / N,N-dimethyl-formamide

With pyridine; N-Bromosuccinimide; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.021

Reference yield:

: 260969-00-4
N-[3-(Carbomethoxy)phenyl] 4-fluorobenzenesulfonamide

: 1244641-39-1
N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane

2: N-Bromosuccinimide / N,N-dimethyl-formamide

With N-Bromosuccinimide; lithium hexamethyldisilazane; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.021