ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate

Base Information

Chemical Name:ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate
CAS No.:190953-89-0
Molecular Formula:C₂₆H₃₂N₆O₂
Molecular Weight:460.579
Hs Code.:

Synonyms:ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate

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Chemical Property of ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate

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Technology Process of ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate

There total 4 articles about ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 105-36-2
ethyl bromoacetate

: 190953-88-9
N-(phenylmethyl)-N-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)-1,2-diaminoethane

: 190953-89-0
ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 ℃; for 4h;
DOI:10.1021/jm980569z

Reference yield:

: 177948-00-4
3-(5-[1,2,4-triazol-4-yl]-1H-indol-3-yl)propan-1-ol

: 190953-89-0
ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) MeSO₂Cl, Et₃N, 2.) K₂CO₃, NaI / 1.) THF, 90 min, 2.) THF, i-PrOH, reflux, 9 h

2: 85 percent / AcOH, NaBH₃CN / methanol / 22 h / Ambient temperature

3: 83 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

4: 62 percent / K₂CO₃ / dimethylformamide / 4 h / 0 °C

With sodium cyanoborohydride; potassium carbonate; acetic acid; methanesulfonyl chloride; triethylamine; trifluoroacetic acid; sodium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980569z

Reference yield:

: 190953-86-7
2-<3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propylamino>ethylcarbamic acid tert-butyl ester

: 190953-89-0
ethyl 2-<(phenylmethyl)-(3-<5-(1,2,4-triazol-4-yl)-1H-indol-3-yl>propyl)amino>ethylaminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / AcOH, NaBH₃CN / methanol / 22 h / Ambient temperature

2: 83 percent / TFA / CH₂Cl₂ / 5 h / Ambient temperature

3: 62 percent / K₂CO₃ / dimethylformamide / 4 h / 0 °C

With sodium cyanoborohydride; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980569z