C₄₈H₇₁N₇O₁₃

Base Information

• Chemical Name: C₄₈H₇₁N₇O₁₃
• CAS No.: 1027906-73-5
• Molecular Formula: C₄₈H₇₁N₇O₁₃
• Molecular Weight: 954.131
• Mol file: 1027906-73-5.mol

Synonyms:C₄₈H₇₁N₇O₁₃

Chemical Property of C₄₈H₇₁N₇O₁₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₇₁N₇O₁₃

There total 12 articles about C₄₈H₇₁N₇O₁₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate (3496-11-5) → C48H71N7O13 (1027906-73-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

2: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

3: 78 percent / N-methylmorpholine hydrochloride / dimethylformamide / 4 h / -10 - 0 °C

4: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

5: N-methylmorpholine NMM, HOBt, N,N'-dicyclohexylcarbodiimide DCC / dimethylformamide / 0 deg C, 2 h, 2.) RT, 24 h

With 4-methyl-morpholine; hydrogen; N-methylmorpholine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/0223-5234(92)90113-F

Reference yield:

ethyl N-(benzyloxycarbonyl)-L-valylglycinate (2766-17-8) → C48H71N7O13 (1027906-73-5)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

2: 78 percent / N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

3: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

4: 78 percent / N-methylmorpholine hydrochloride / dimethylformamide / 4 h / -10 - 0 °C

5: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

6: N-methylmorpholine NMM, HOBt, N,N'-dicyclohexylcarbodiimide DCC / dimethylformamide / 0 deg C, 2 h, 2.) RT, 24 h

With 4-methyl-morpholine; hydrogen; N-methylmorpholine hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/0223-5234(92)90113-F

Reference yield:

Z-D(tBu)-OH (5545-52-8) → C48H71N7O13 (1027906-73-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N-methylmorpholine NMM / dimethylformamide / 0.05 h / -10 °C

2: 78 percent / N-methylmorpholine hydrochloride / dimethylformamide / 4 h / -10 - 0 °C

3: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

4: N-methylmorpholine NMM, HOBt, N,N'-dicyclohexylcarbodiimide DCC / dimethylformamide / 0 deg C, 2 h, 2.) RT, 24 h

With 4-methyl-morpholine; hydrogen; N-methylmorpholine hydrochloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/0223-5234(92)90113-F

upstream raw materials:

Asp(OtBu)-Val-Val-Gly-OEt

Boc-Tyr-D-Ala-Phe-OH

2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate

ethyl N-(benzyloxycarbonyl)-L-valylglycinate