Z-VAL-GLY-OET

Base Information

• Chemical Name: Z-VAL-GLY-OET
• CAS No.: 2766-17-8
• Molecular Formula: C17H24N2O5
• Molecular Weight: 336.388
• Hs Code.: 2924299090
• Mol file: 2766-17-8.mol

Synonyms:ethyl ester of N-benzyloxycarbonyl-L-valylglycine;ethyl N-(benzyloxycarbonyl)-L-valylglycinate;Z-Val-Gly-OC2H5;Z-VAL-GLY-OET;Cbz-valylglycine ethyl ester;Nα-(benzyloxycarbonyl)-L-valyl-glycine ethyl ester;ethyl [(2S)-2-(benzyloxycarbonylamino)-3-methylbutanoylamino]acetate;

Chemical Property of Z-VAL-GLY-OET

Chemical Property:

• Vapor Pressure: 9.01E-11mmHg at 25°C
• Melting Point: 105 °C
• Boiling Point: 516.4±40.0 °C(Predicted)
• PKA: 11.04±0.46(Predicted)
• PSA: 93.73000
• Density: 1.146±0.06 g/cm3(Predicted)
• LogP: 2.39850
• Storage Temp.: -15°C

Purity/Quality:

97% ^*data from raw suppliers

Z-Val-Gly-OEt 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-VAL-GLY-OET

There total 40 articles about Z-VAL-GLY-OET which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) + glycine ethyl ester hydrochloride (623-33-6) → ethyl N-(benzyloxycarbonyl)-L-valylglycinate (2766-17-8)

Guidance literature:

With 3,3'-(phenylphosphinylidene)bis<2(3H)-benzothiazolone; triethylamine; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1246/bcsj.58.3291

Reference yield: 65.8%

glycine ethyl ester hydrochloride (623-33-6) + Cbz-Val-F (133010-20-5) → ethyl N-(benzyloxycarbonyl)-L-valylglycinate (2766-17-8)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; Ambient temperature;

DOI:10.1021/jo00008a005

Reference yield: 63.0%

1-(Cbz-valyl)-3,5-dimethylpyrazole (261729-63-9) + GlyOEt*HCl (459-73-4) → ethyl N-(benzyloxycarbonyl)-L-valylglycinate (2766-17-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 1.33333h; Heating;

DOI:10.3987/COM-99-S51

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

glycine ethyl ester hydrochloride

GlyOEt*HCl

N-[(benzyloxy)carbonyl]-D-valine

Downstream raw materials:

valylglycine

C₄₈H₇₁N₇O₁₃

((S)-2-{(S)-2-[(S)-2-((S)-2-{(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-3-carbamoyl-propionylamino]-3-methyl-butyrylamino}-3-methyl-butyrylamino)-acetic acid ethyl ester

Z-Asp(OtBu)-Val-Val-Gly-OEt