3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine

Base Information

• Chemical Name: 3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine
• CAS No.: 1373245-74-9
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.301
• Mol file: 1373245-74-9.mol

Synonyms:3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine

Chemical Property of 3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine

There total 7 articles about 3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-(2-chlorophenoxy)acetate (52094-97-0) + 3,5-dimethylaminoaniline (108-69-0) → 3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine (1373245-74-9)

Guidance literature:

With 2-dicyclohexylphosphino-2,4,6-triisopropylbiphenyl; palladium diacetate; caesium carbonate; In toluene; at 150 ℃; for 1.5h; Microwave irradiation;

DOI:10.1055/s-0033-1338508

Reference yield: 94.0%

2-Iodophenol (533-58-4) + ethyl bromoacetate (105-36-2) + 3,5-dimethylaminoaniline (108-69-0) → 3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine (1373245-74-9)

Guidance literature:

With 2-dicyclohexylphosphino-2,4,6-triisopropylbiphenyl; palladium diacetate; caesium carbonate; In toluene; at 150 ℃; for 3h; Microwave irradiation;

DOI:10.1055/s-0033-1338508

Reference yield: 93.0%

2-([(ethoxycarbonyl)methylene]oxy)-1-iodobenzene (90794-32-4) + 3,5-dimethylaminoaniline (108-69-0) → 3,4-dihydro-4-(3,5-dimethylphenyl)-3-oxo-2H-1,4-benzoxazine (1373245-74-9)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 90 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1055/s-0031-1290346

upstream raw materials:

2-Iodophenol

2-hydroxybromobenzene

2-([(ethoxycarbonyl)methylene]oxy)-1-iodobenzene

3,5-dimethylaminoaniline