Technology Process of N-{2-[3-Fluoro-5-(4-isopropyl-piperazin-1-yl)-phenyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl}-methanesulfonamide
There total 7 articles about N-{2-[3-Fluoro-5-(4-isopropyl-piperazin-1-yl)-phenyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonyl}-methanesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methanesulfonamide;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 25 ℃;
for 1h;
2-[3-fluoro-5-(4-isopropyl-piperazin-1-yl)-phenyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide; mineral oil;
at 25 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ethanol / 2 h / Reflux
2.1: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 5 h / 25 °C
3.1: trifluoroacetic acid; triethylsilane / 1 h / 25 °C
4.1: potassium hydroxide / L-proline; copper(l) iodide / dimethyl sulfoxide / 2 h / 120 °C
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 12 h / 60 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 25 °C
6.2: 1 h / 25 °C
With
triethylsilane; lithium hydroxide monohydrate; water; sodium hydride; trifluoroacetic acid; potassium hydroxide;
copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; L-proline;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
2.1: Diels-Alder Reaction / 4.1: Ullmann Reaction;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ethanol / 2 h / Reflux
2.1: water / ytterbium(III) trifluoromethanesulfonate hydrate / tetrahydrofuran / 5 h / 25 °C
3.1: trifluoroacetic acid; triethylsilane / 1 h / 25 °C
4.1: potassium hydroxide / L-proline; copper(l) iodide / dimethyl sulfoxide / 2 h / 120 °C
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 12 h / 60 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 25 °C
6.2: 1 h / 25 °C
With
triethylsilane; lithium hydroxide monohydrate; water; sodium hydride; trifluoroacetic acid; potassium hydroxide;
copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; L-proline;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
2.1: Diels-Alder Reaction / 4.1: Ullmann Reaction;
