1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

Base Information

Chemical Name:1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one
CAS No.:328397-78-0
Molecular Formula:C₁₈H₂₆O₄
Molecular Weight:306.402
Hs Code.:

Synonyms:1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

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Chemical Property of 1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

Chemical Property:

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Technology Process of 1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

There total 1 articles about 1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52449-32-8
1-[4-(bromomethyl)phenyl]-2,2-dimethyl-1-propanone

: 100-79-8,36543-79-0
(R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol

: 328397-78-0
1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

Guidance literature:: (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

1-[4-(bromomethyl)phenyl]-2,2-dimethyl-1-propanone; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Further stages.;
DOI:10.1021/jm000264w

Reference yield:

: 328397-78-0
1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

: 328397-43-9
1-[4-(2,3-dihydroxy-propoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm000264w

Reference yield:

: 328397-78-0
1-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxymethyl)-phenyl]-2,2-dimethyl-propan-1-one

: 1-(4-{2-[4-(2,2-dimethyl-propionyl)-benzyloxy]-1-[4-(2,2-dimethyl-propionyl)-benzyloxymethyl]-ethoxymethyl}-phenyl)-2,2-dimethyl-propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.5 N aq. HCl / tetrahydrofuran / 3 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 69 percent / tetrahydrofuran / 24 h / 60 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jm000264w