Technology Process of dibenzyl 2-(hex-5-ynyl)malonate
There total 2 articles about dibenzyl 2-(hex-5-ynyl)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
malonic acid dibenzyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 25 ℃;
for 1h;
Inert atmosphere;
1-iodo-5-hexyne;
In
N,N-dimethyl-formamide;
at 0 - 60 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ol300278x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium iodide / acetone / 72 h / Inert atmosphere; Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 25 °C / Inert atmosphere
2.2: 12 h / 0 - 60 °C / Inert atmosphere
With
sodium hydride; sodium iodide;
In
N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol300278x
- Guidance literature:
-
dibenzyl 2-(hex-5-ynyl)malonate;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
acetaldehyde;
In
tetrahydrofuran;
at -78 ℃;
for 0.25h;
Inert atmosphere;
With
ammonium chloride;
In
tetrahydrofuran; water;
Inert atmosphere;
DOI:10.1021/ol300278x
