Technology Process of dibenzyl 2-(2-oxopropyl)cyclohexane-1,1-dicarboxylate
There total 4 articles about dibenzyl 2-(2-oxopropyl)cyclohexane-1,1-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C25H28O5;
With
indium(III) triflate; (η5-indenyl)ruthenium(bis(triphenylphosphine))chloride;
In
tetrahydrofuran;
at 64 ℃;
for 2h;
Inert atmosphere;
With
N,N,N',N'-tetramethylguanidine;
In
tetrahydrofuran;
at 64 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/ol300278x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium iodide / acetone / 72 h / Inert atmosphere; Reflux
2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 25 °C / Inert atmosphere
2.2: 12 h / 0 - 60 °C / Inert atmosphere
3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
3.2: 0.25 h / -78 °C / Inert atmosphere
3.3: Inert atmosphere
4.1: indium(III) triflate; (η5-indenyl)ruthenium(bis(triphenylphosphine))chloride / tetrahydrofuran / 2 h / 64 °C / Inert atmosphere
4.2: 24 h / 64 °C / Inert atmosphere
With
indium(III) triflate; (η5-indenyl)ruthenium(bis(triphenylphosphine))chloride; sodium hydride; sodium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
4.2: Michael condensation;
DOI:10.1021/ol300278x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 0.25 h / -78 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: indium(III) triflate; (η5-indenyl)ruthenium(bis(triphenylphosphine))chloride / tetrahydrofuran / 2 h / 64 °C / Inert atmosphere
2.2: 24 h / 64 °C / Inert atmosphere
With
indium(III) triflate; (η5-indenyl)ruthenium(bis(triphenylphosphine))chloride; lithium diisopropyl amide;
In
tetrahydrofuran;
2.2: Michael condensation;
DOI:10.1021/ol300278x
